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Drug


imipramine
generic
 



Generic Name:imipramine
Pronounced:ih MIH pra meen
Brand Names:Tofranil, Tofranil-PM

What is the most important information I should know about imipramine?

While you are taking imipramine you may need to be monitored for worsening symptoms of depression and/or suicidal thoughts at the start of therapy or when doses are changed. This concern about the increased risk of suicidal thoughts or behaviors may be greater if you are 18 years of age or younger and are taking imipramine. In patients younger than 18 years, the period of risk may extend beyond start of therapy or when doses are changed. Your doctor may want you to monitor for the following symptoms: anxiety, panic attacks, difficulty sleeping, irritability, hostility, impulsivity, severe restlessness, and mania (mental and/or physical hyperactivity). These symptoms may be associated with the development of worsening symptoms of depression and/or suicidal thoughts or actions. Contact your healthcare provider if you develop any new or worsening mental health symptoms during treatment with imipramine. Do not stop taking imipramine.
It may be 4 weeks or more before you start to feel better, but do not stop taking imipramine without first talking to your doctor.
Use caution when driving, operating machinery, or performing other hazardous activities. Imipramine may cause drowsiness or dizziness. If you experience drowsiness or dizziness, avoid these activities.
Dizziness is likely to occur when you rise from a sitting or lying position. Rise slowly to prevent dizziness and a possible fall.
Use alcohol cautiously. Alcohol may increase drowsiness and dizziness while you are taking imipramine.

What is imipramine?
Imipramine is in a class of drugs called tricyclic antidepressants. Imipramine affects chemicals in the brain that may become unbalanced and cause depression.
Imipramine is used to relieve symptoms of depression such as feelings of sadness, worthlessness, or guilt; loss of interest in daily activities; changes in appetite; tiredness; sleeping too much; insomnia; and thoughts of death or suicide.
imipramine may also be used for purposes other than those listed in this medication guide.

What should I discuss with my healthcare provider before taking imipramine?
Do not take imipramine if you have taken a monoamine oxidase inhibitor such as isocarboxazid (Marplan), phenelzine (Nardil), or tranylcypromine (Parnate) within the last 14 days.
Before taking imipramine, tell your doctor if you have
  • liver disease;
  • kidney disease;
  • asthma,
  • thyroid disease,
  • diabetes,
  • stomach or intestinal problems,
  • high blood pressure or heart disease,
  • had a heart attack in the last 6 weeks,
  • an enlarged prostate or difficulty urinating, or
  • glaucoma.
You may not be able to take imipramine, or you may require a dosage adjustment or special monitoring during therapy if you have any of the conditions listed above.
While you are taking imipramine you may need to be monitored for worsening symptoms of depression and/or suicidal thoughts at the start of therapy or when doses are changed. This concern about the increased risk of suicidal thoughts or behaviors may be greater if you are 18 years of age or younger and are taking imipramine. In patients younger than 18 years, the period of risk may extend beyond start of therapy or when doses are changed. Your doctor may want you to monitor for the following symptoms: anxiety, panic attacks, difficulty sleeping, irritability, hostility, impulsivity, severe restlessness, and mania (mental and/or physical hyperactivity). These symptoms may be associated with the development of worsening symptoms of depression and/or suicidal thoughts or actions. Contact your healthcare provider if you develop any new or worsening mental health symptoms during treatment with imipramine. Do not stop taking imipramine.
It is not known whether imipramine will be harmful to an unborn baby. Do not take imipramine without first talking to your doctor if you are pregnant or could become pregnant during treatment.
Imipramine passes into breast milk and may affect a nursing baby. Do not take imipramine without first talking to your doctor if you are breast-feeding a baby.
If you are over 60 years of age, you may be more likely to experience side effects such as drowsiness, dizziness, unsteadiness, feeling uncoordinated, and low blood pressure. Your doctor may prescribe a lower dose of this medication.

How should I take imipramine?

Take imipramine exactly as directed by your doctor. If you do not understand these directions, ask your pharmacist, nurse, or doctor to explain them to you.
Take each oral dose with a full glass (8 oz) of water.
Imipramine may be taken several times a day or in one daily dose (usually at bedtime). Follow your doctor's instructions.
Imipramine is also available as an injection that is usually administered by a healthcare provider. If you are administering imipramine injection at home, your doctor or nurse will give you detailed preparation, administration, and storage instructions.
It may be 4 weeks or more before you start to feel better, but do not stop taking imipramine without first talking to your doctor.
Store imipramine at room temperature away from moisture and heat.

What happens if I miss a dose?
Take the missed dose as soon as you remember. If it is almost time for the next regularly scheduled dose, skip the missed dose and take the next one as directed. Do not take a double dose of this medication unless otherwise directed by your doctor.

What happens if I overdose?
Seek emergency medical attention if an overdose is suspected.
Symptoms of an imipramine overdose include seizures, confusion, drowsiness, agitation, hallucinations, and low blood pressure (dizziness, fatigue, fainting).

What should I avoid while taking imipramine?
Use caution when driving, operating machinery, or performing other hazardous activities. Imipramine may cause drowsiness or dizziness. If you experience drowsiness or dizziness, avoid these activities.
Dizziness is likely to occur when you rise from a sitting or lying position. Rise slowly to prevent dizziness and a possible fall.
Use alcohol cautiously. Alcohol may increase drowsiness and dizziness while taking imipramine.
Do not stop taking imipramine suddenly. This could cause symptoms such as nausea, headache, and malaise.

What are the possible side effects of imipramine?

If you experience any of the following serious side effects, stop taking imipramine and contact your doctor immediately or seek emergency medical treatment:
  • an allergic reaction (difficulty breathing; closing of the throat; swelling of the lips, face, or tongue; or hives);
  • seizures;
  • a fast or irregular heartbeat;
  • a heart attack;
  • high blood pressure (blurred vision, severe headache);
  • difficulty urinating; or
  • fever with increased sweating, muscle stiffness, or severe muscle weakness.
Other, less serious side effects may be more likely to occur. Continue to take imipramine and talk to your doctor if you experience
  • drowsiness or dizziness;
  • dry mouth and eyes;
  • constipation;
  • mild tremor;
  • sweating;
  • mild agitation, weakness, or headache;
  • ringing in the ears;
  • nausea; or
  • loss of weight or appetite.
Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome.

What other drugs will affect imipramine?
Do not take imipramine if you have taken a monoamine oxidase inhibitor such as isocarboxazid (Marplan), phenelzine (Nardil), or tranylcypromine (Parnate) within the last 14 days.
Imipramine may increase the effects of other drugs that cause drowsiness, including other antidepressants, alcohol, antihistamines, sedatives (used to treat insomnia), pain relievers, anxiety medicines, and muscle relaxants. Tell your doctor about all medicines that you are taking, and do not take any other prescription or over-the-counter medicines without first talking to your doctor.
Drugs other than those listed here may also interact with imipramine. Talk to your doctor and pharmacist before taking any prescription or over-the-counter medicines, including vitamins, minerals, and herbal products.

Where can I get more information?
Your pharmacist has additional information about imipramine written for health professionals that you may read.

What does my medication look like?
Imipramine is available with a prescription generically and under the brand name Tofranil. Other brand or generic formulations may also be available. Ask your pharmacist any questions you have about this medication, especially if it is new to you.
  • Tofranil 10 mg--triangular, coral, sugar-coated tablets
  • Tofranil 25 mg--round, coral, sugar-coated tablets
  • Tofranil 50 mg--round, coral, sugar-coated tablets

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise.

Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides.

The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.


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